Jeffrey E Saffitz Selected Research

gamma Catenin (Plakoglobin)

2/2016	Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells.
9/2013	Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.
3/2013	Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
10/2011	Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy.
4/2011	Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.
3/2009	A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.
11/2007	A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy.
9/2006	Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy.
6/2005	Dependence of electrical coupling on mechanical coupling in cardiac myocytes: insights gained from cardiomyopathies caused by defects in cell-cell connections.
5/2004	Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).

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Jeffrey E Saffitz Research Topics

Disease

23	Cardiomyopathies (Cardiomyopathy) 01/2021 - 01/2004
11	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 11/2014 - 05/2004
9	Heart Failure 01/2020 - 02/2002
4	Myocardial Ischemia (Ischemic Heart Diseases) 08/2007 - 06/2002
3	Inflammation (Inflammations) 01/2020 - 10/2011
3	Fibrosis (Cirrhosis) 01/2020 - 09/2006
3	Heart Diseases (Heart Disease) 11/2019 - 08/2007
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2018 - 11/2012
3	Cardiac Sudden Death (Sudden Cardiac Arrest) 11/2012 - 11/2003
3	Ischemia 09/2007 - 05/2003
2	Necrosis 01/2021 - 10/2019
2	Atrial Fibrillation 01/2020 - 06/2006
2	Cicatrix (Scar) 01/2019 - 02/2003
2	Sarcoidosis (Schaumann Disease) 08/2013 - 10/2011
2	Myocarditis (Carditis) 08/2013 - 10/2011
2	Ventricular Tachycardia 08/2012 - 06/2003
2	Sudden Death 01/2012 - 08/2009
2	Naxos disease 11/2007 - 05/2004
2	Myocardial Infarction 02/2003 - 06/2002
1	Hypertrophy 01/2020
1	Ventricular Remodeling 01/2020
1	Ectodermal Dysplasia (Aplasia Cutis Congenita) 01/2020
1	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 01/2020
1	Granulomatosis with Polyangiitis (Wegener's Granulomatosis) 08/2013
1	Crohn Disease (Crohn's Disease) 08/2013
1	Tuberculosis (Tuberculoses) 08/2013
1	Sudden Infant Death (SID) 01/2012
1	Desmin-Related Myofibrillar Myopathy 08/2010
1	Skin Diseases (Skin Disease) 05/2009
1	Infections 09/2007
1	Atherosclerotic Plaque (Atheroma) 12/2005
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 07/2004
1	Amyloidosis 07/2004
1	Left Ventricular Dysfunction 05/2004
1	Cardiomegaly (Heart Hypertrophy) 04/2004
1	Restrictive Cardiomyopathy 04/2004

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 10/2019 - 06/2003
15	Connexin 43 (Connexin43)IBA 01/2020 - 02/2002
10	gamma Catenin (Plakoglobin)IBA 02/2016 - 05/2004
9	ConnexinsIBA 01/2020 - 11/2003
7	Desmoplakins (Desmoplakin)IBA 01/2020 - 01/2004
3	DesminIBA 08/2010 - 07/2004
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 12/2005
2	ParaffinIBA 01/2020 - 01/2012
2	CytokinesIBA 10/2019 - 10/2011
2	phospholambanIBA 05/2019 - 11/2012
2	Pharmaceutical PreparationsIBA 02/2016 - 12/2014
2	Desmoglein 2IBA 10/2010 - 09/2006
1	Galectin 3 (LGALS3)IBA 01/2021
1	Cyclophilin AIBA 01/2021
1	Peptides (Polypeptides)IBA 01/2021
1	calpastatinIBA 01/2021
1	Glutamic Acid (Glutamate)FDA Link 01/2020
1	Formaldehyde (Formol)FDA Link 01/2020
1	GlutamatesIBA 01/2020
1	GlycogenIBA 01/2020
1	D-Aspartic Acid (D Aspartate)IBA 01/2020
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2020
1	Trans-Activators (Trans-Acting Factor)IBA 01/2020
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2020
1	TOR Serine-Threonine KinasesIBA 01/2020
1	Serine (L-Serine)FDA Link 01/2020
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2019
1	3- (4- methylphenylsulfonyl)- 2- propenenitrileIBA 10/2019
1	Glycogen Synthase (Synthase I)IBA 05/2019
1	Discs Large Homolog 1 ProteinIBA 05/2019
1	FilaminsIBA 01/2018
1	Phosphotransferases (Kinase)IBA 02/2016
1	Transcription Factors (Transcription Factor)IBA 02/2016
1	SB 216763IBA 06/2014
1	Cathepsin KIBA 08/2013
1	Sodium Channels (Sodium Channel)IBA 03/2013
1	DNA (Deoxyribonucleic Acid)IBA 01/2012
1	InterleukinsIBA 10/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2011
1	CateninsIBA 10/2011
1	Interleukin-6 (Interleukin 6)IBA 10/2011
1	Cadherins (E-Cadherin)IBA 10/2010
1	Complement System Proteins (Complement)IBA 09/2007
1	LipidsIBA 09/2006
1	PlakophilinsIBA 09/2006
1	AcidsIBA 08/2005
1	Small Heat-Shock ProteinsIBA 07/2004
1	alpha-Crystallin B ChainIBA 07/2004
1	Amyloid (Amyloid Fibrils)IBA 07/2004
1	Cell Adhesion MoleculesIBA 05/2004
1	salicylhydroxamic acid (SHAM)IBA 05/2004
1	Muromonab-CD3 (Muromonab CD3)FDA Link 05/2004
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/2004
1	SteroidsIBA 05/2004
1	Thomsen-Friedenreich antibodiesIBA 05/2004
1	JNK Mitogen-Activated Protein KinasesIBA 04/2004
1	Protein Kinase CIBA 04/2004
1	PPAR gammaIBA 03/2004

Therapy/Procedure

4	Heart Transplantation (Grafting, Heart) 10/2015 - 05/2004
3	Therapeutics 02/2016 - 02/2003
3	Ligation 05/2004 - 06/2002
1	Radiofrequency Ablation 01/2019
1	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 11/2012
1	Plasmapheresis 05/2004